Laboratory of Multi-omic Integrative Bioinformatics

Projects

We develop open-source computational tools and resources to advance multi-omics biology and medicine. All of our software is freely available on GitHub.

Causal Integrated Gradients
Causal Integrated Gradients

A scalable gradient-based feature attribution method that follows the causal structure of the features.

LipoGrid
LipoGrid

A high-throughput multi-omics perturbation screen to dissect the genetic architecture of lipid metabolism.

FOCUS
FOCUS

FOCUS is an end-to-end Python Framework for preprocessing, alignment, and resolution-matched integration of spatial multi-omics data.

Multiverse
Multiverse

Multiverse is a reproducible benchmarking tool for multimodal single-cell integration, without making bioinformaticians become infrastructure engineers.

Subcellspace
Subcellspace

Subcellspace integrates subcellular resolution transcriptomics with conventional microscopy to map RNA localisation within individual cells. It leverages deep neural network architectures to fuse morphological and molecular information at unprecedented resolution.

All Projects

Causal Integrated Gradients
Causal Integrated Gradients

A scalable gradient-based feature attribution method that follows the causal structure of the features.

LipoGrid
LipoGrid

A high-throughput multi-omics perturbation screen to dissect the genetic architecture of lipid metabolism.

FOCUS
FOCUS

FOCUS is an end-to-end Python Framework for preprocessing, alignment, and resolution-matched integration of spatial multi-omics data.

Multiverse
Multiverse

Multiverse is a reproducible benchmarking tool for multimodal single-cell integration, without making bioinformaticians become infrastructure engineers.

MIMA
MIMA

MIMA is a Multimodal Variational Autoencoder designed for the integration of heterogeneous molecular layers, enabling a comprehensive multimodal representation of the cellular state.

Subcellspace
Subcellspace

Subcellspace integrates subcellular resolution transcriptomics with conventional microscopy to map RNA localisation within individual cells. It leverages deep neural network architectures to fuse morphological and molecular information at unprecedented resolution.